La Casa de los Azulejos (Tile House) is one of the most beautiful pieces of novo-spanish baroque civil arquitecture. It is a work of art framed by talavera that fully covers its facade. It was said to be a refuge for supporters of the conquistador Hernán Cortés. Its first owner was Hernando Avila, followed by Damian Hernandez. It was the residence of the Valle de Orizaba counts, in fact one of the descendants decided to coat the exterior with polychromatic mosaics in the eighteenth century.

From 1881 the building became the Jockey Club and later the Casa del Obrero Mundial. At that time the calle 5 de mayo was the most elegant avenue in Porfiriato. It is a Sanborns since 1919. Two murals are preserved inside: Pavorreales by Palcologne in 1918 and Omniscience by José Clemente Orozco in 1925.