The museum honors the Soviet leader, by getting close to his environment and circles from his home in México. Trotsky in one of the main characters of the Revolution of October in Rusia, 1917; as well as an organizator of the New Soviet State.

Trotsky was expelled from his country after Stalin took power in 1929 and was obliged to assume exile. By the end of 1936, President Lázaro Cárdenas gave him political asylum in México. Trotsky found protection with Diego Rivera and Frida Kahlo until 5th January, 1939 when he acquired the house where the museum is now.

In addition to guided visits, the place offers cultural activities of all kinds, such as book presentations, Film Series and workshops.